“Unlocking the Potential for Paralysis Recovery: A Proposal for Collaboration with the Department of Veterans Affairs”

Dear [Department of Veterans Affairs],

I am writing to propose an exciting opportunity for the Department of Veterans Affairs and for the brave men and women who have served our country. As you may be aware, recent scientific breakthroughs in the field of spinal cord injury research have led to a significant discovery regarding the neurons that may restore walking after paralysis. This research, published in the prestigious journal “Nature,” demonstrates the potential for the treatment of paralysis in a way that has never been seen before.

I believe that this discovery has the potential to significantly benefit our country’s Veterans, many of whom have suffered spinal cord injuries as a result of their service. As a result, I propose that the Department of Veterans Affairs work with the leading scientists involved in this research to continue this work with the help of volunteer Veterans who have suffered spinal cord injuries.

This collaboration would involve the VA providing support for the continuation of the research, while the scientists involved would be responsible for conducting the research and providing the necessary medical care for the volunteer Veterans. The goal of this collaboration would be to not only further the scientific understanding of paralysis, but also to provide real-world benefits for those who have suffered as a result of their service to our country.

I believe that this proposal would be a win-win for all involved. Not only would it provide our Veterans with the opportunity to potentially regain mobility and improve their quality of life, but it would also be a valuable investment in the future of paralysis treatment. Over the long-term, this investment could lead to decreased health care costs for the VA, as well as improved outcomes for Veterans who have suffered spinal cord injuries.

In conclusion, I believe that this proposal has the potential to make a real and meaningful impact on the lives of our country’s Veterans. I would be honored to discuss this proposal with you further and answer any questions you may have.

Thank you for your consideration.

Sincerely, [Your Name]

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Yes I have used an AI to generate this because it is a very complicated Idea..

but so simple

540 | Nature | Vol 611 | 17 November 2022Article The neurons that restore walking after paralysis

the AI generated Outline

Sure, I can break down the information in parts 1 through 17 as follows:

Part 1: Introduction

• This article is about a study of neurons in the nervous system and their role in restoring walking ability after paralysis.

Part 2: Purpose of the Study

• The purpose of the study was to identify specific neurons that can restore walking after spinal cord injury.

Part 3: Research Methodology

• The researchers used a combination of genetic and optogenetic techniques to identify and manipulate specific neurons in mice.

Part 4: Findings

• The researchers identified two specific neurons in the lumbosacral spinal cord that play a critical role in restoring walking after paralysis.

Part 5: Role of the Two Neurons

• These two neurons are responsible for generating the proper muscle activity patterns necessary for walking.

Part 6: Optogenetics

• The researchers used optogenetics to activate the two neurons, leading to the restoration of walking in the paralyzed mice.

Part 7: Activation of the Two Neurons

• The two neurons were activated using light stimulation delivered through optical fibers implanted in the spinal cord.

Part 8: Restoration of Walking

• The researchers observed that the restoration of walking was not immediate and required repeated stimulation over several days.

Part 9: Implications of the Findings

• These findings have important implications for the development of therapies for spinal cord injury and other conditions that cause paralysis.

Part 10: Limitations of the Study

• The study was conducted in mice and further research is needed to determine if the findings can be translated to humans.

Part 11: Future Research

• The researchers plan to further study the two neurons and their role in other motor behaviors.

Part 12: Conclusion

• The researchers have identified two specific neurons in the lumbosacral spinal cord that play a critical role in restoring walking after paralysis and have demonstrated the potential of optogenetics as a therapy for spinal cord injury.

Part 13: About the Authors

• The authors of the paper are Chris Kathe, Michelle A. Skinnider, Terrence H. Hutson, among others.

Part 14: Journal and Publication Information

• The paper was published in the journal “Nature” in November 2022.

Part 15: Article’s DOI and Link

• The DOI for the article is https://doi.org/10.1038/s41586-022-05385-7 and the link to the article is https://rdcu.be/c5sXg.

Part 16: Related Studies

• The article is cited by other studies in the fields of genetics of the nervous system and spinal cord injury.

Part 17: Additional Information

• The article was received on November 9, 2021, accepted on September 23, 2022, and published on November 9, 2022. It is part of the Springer Nature SharedIt content-sharing initiative.

Cite this article

Kathe, C., Skinnider, M.A., Hutson, T.H. et al. The neurons that restore walking after paralysis. Nature 611, 540–547 (2022). https://doi.org/10.1038/s41586-022-05385-7

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I have sen a lot of wheel chairs and a lot of walkers.. I think you would have more volunteers then you can handle.. especially if you publically posted this and asked doctor to inquire of patients if they wish to participate..

I am not associate in anyway with the individuals who created this paper other then reading it.. and is astounded me what this discovery means s a mere laymen..

With treatment some spinal injuries may heal

This is amazing and the tech aint that complicated to me.. The issue here is if the VA, Social Security, Department of Defense, DARPA, Surgeon General are willing to cooperate and contact the creators of this.. And see if they are ready for Large scale testing.. So all the mass data can be collected and refine the treatment..

I am sure those with no hope, If you dont lie to them.. We have an experiment that involves getting your body to fix spinal damage.. Its experimental, but we need voluteers..

You will get colorful replies that offend sensibilities followed by the patient explaining, “We are in Doc..”

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The next step in this research, as described in the article “The Neurons that Restore Walking After Paralysis” by Kathe et al, would require further studies and experiments to understand the underlying mechanisms and to validate the findings. This would involve testing the effectiveness of the stimulation of the two neurons on a larger scale, exploring different stimulation protocols, and improving the design and safety of the implantable devices. Additionally, the study could be expanded to investigate the potential for functional recovery in patients with other forms of spinal cord injury.

that is the next step and I agree with the points..

the idea is that I am sure the VA can provide the participants for the next step in this experiment

it just needs you

If you agree contact you congressman, this research needs more then just a boost

it need to be science fact